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Article

The spectrum of exercise tolerance in mitochondrial myopathies: a study of 40 patients.

Brain : a journal of neurology - 1 Feb 2003

Taivassalo Tanja, Jensen Tina Dysgaard, Kennaway Nancy, DiMauro Salvatore, Vissing John, Haller Ronald G

Abstract excerpt

Impaired skeletal muscle oxidative phosphorylation in patients with severe mitochondrial respiratory chain defects results in disabling exercise intolerance that is associated with a markedly blunted capacity of muscle to increase oxygen utilization in relation to circulatory and ventilatory responses that increase oxygen delivery to muscle during exercise. The range of oxidative limitation and the relationship...

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Source

Identifiers

PMID: 12538407
DOI: 10.1093/brain/awg028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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