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Article

Evidence of a Causal Effect of Estradiol on Fracture Risk in Men.

The Journal of clinical endocrinology and metabolism - 1 Feb 2019

Nethander Maria, Vandenput Liesbeth, Eriksson Anna L, Windahl Sara, Funck-Brentano Thomas, Ohlsson Claes

Abstract excerpt

Context: Observational studies indicate that serum estradiol (E2) is more strongly associated with bone mineral density (BMD) than serum testosterone (T) is, whereas both E2 and T associate with fracture risk in men. Objective: To evaluate the possible causal effect of serum E2 and T on fracture risk in men. Design, Setting, and Participants: A Mendelian randomization (MR) approach was undertaken using...

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Source

Identifiers

PMID: 30215726
DOI: 10.1210/jc.2018-00934

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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