Causal Link Between Vitamin D and Total Testosterone in Men: A Mendelian Randomization Analysis

Abstract excerpt

CONTEXT: Low circulating vitamin D levels have been associated with lower total testosterone levels. These epidemiological associations, if true, would have public health importance because vitamin D deficiency is common and correctable. We tested whether genetically lowered vitamin D levels were associated with lower total testosterone (T), using Mendelian randomization (MR) methodology. DESIGN AND SETTING: A...