Article
Differential requirement of Hippo cascade during CTNNB1 or AXIN1 mutation-driven hepatocarcinogenesis.
Hepatology (Baltimore, Md.) - 1 Jun 2023
Liang Binyong, Wang Haichuan, Qiao Yu, Wang Xue, Qian Manning, Song Xinhua, Zhou Yi, Zhang Yi, Shang Runze, Che Li, Chen Yifa, Huang Zhiyong, Wu Hong, Monga Satdarshan P, Zeng Yong, Calvisi Diego F, Chen Xiaoping, Chen Xin
Abstract excerpt
BACKGROUND AND AIMS: Gain-of-function (GOF) mutations of CTNNB1 and loss-of-function (LOF) mutations of AXIN1 are recurrent genetic alterations in hepatocellular carcinoma (HCC). We aim to investigate the functional contribution of Hippo/YAP/TAZ in GOF CTNNB1 or LOF AXIN1 mutant HCCs. APPROACH AND RESULTS: The requirement of YAP/TAZ in c-Met/β-Catenin and c-Met/sgAxin1-driven HCC was analyzed using conditional...
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