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Article

PARP1 is required for chromosomal translocations

9 Apr 2013

Abstract excerpt

Chromosomal translocations are common contributors to malignancy, yet little is known about the precise molecular mechanisms by which they are generated. Sequencing translocation junctions in acute leukemias revealed that the translocations were likely mediated by a DNA double-strand break repair pathway termed nonhomologous end-joining (NHEJ). There are major 2 types of NHEJ: (1) the classical pathway initiated...

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PMID: 23568489
DOI: 10.1182/blood-2012-10-460527

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