Article
Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation.
Nature cell biology - 1 Jul 2005
Qi Ling, Strong Margaret A, Karim Baktiar O, Huso David L, Greider Carol W
Abstract excerpt
Telomeres protect chromosome ends from fusion, degradation and recombination. Loss of telomere function has opposite effects on tumorigenesis: apoptosis, which inhibits tumour growth, and genomic instability, which accelerates tumour formation. Here we describe a new mechanism by which short telomeres inhibit tumorigenesis through interference with oncogenic translocations. In mice that are null for both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.