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SELENOI Functions as a Key Modulator of Ferroptosis Pathway in Colitis and Colorectal Cancer

17 May 2024

Abstract excerpt

Ferroptosis plays important roles both in normal physiology and multiple human diseases. It is well known that selenoprotein named glutathione peroxidase 4 (GPX4) is a crucial regulator for ferroptosis. However, it remains unknown whether other selenoproteins responsible for the regulation of ferroptosis, particularly in gut diseases. In this study, it is observed that Selenoprotein I (Selenoi) prevents...

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PMID: 38757622
DOI: 10.1002/advs.202404073

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