Article
Translational profiling of stress-induced neuroplasticity in the CA3 pyramidal neurons of BDNF Val66Met mice.
Molecular psychiatry - 1 Apr 2018
Gray J D, Rubin T G, Kogan J F, Marrocco J, Weidmann J, Lindkvist S, Lee F S, Schmidt E F, McEwen B S
Abstract excerpt
Genetic susceptibility and environmental factors (such as stress) can interact to affect the likelihood of developing a mood disorder. Stress-induced changes in the hippocampus have been implicated in mood disorders, and mutations in several genes have now been associated with increased risk, such as brain-derived neurotrophic factor (BDNF). The hippocampus has important anatomical subdivisions, and pyramidal...
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