Article
Deficient DNA base-excision repair in the forebrain leads to a sex-specific anxiety-like phenotype in mice.
BMC biology - 30 Jul 2022
Mueller Flavia S, Amport René, Notter Tina, Schalbetter Sina M, Lin Han-Yu, Garajova Zuzana, Amini Parisa, Weber-Stadlbauer Ulrike, Markkanen Enni
Abstract excerpt
BACKGROUND: Neuropsychiatric disorders, such as schizophrenia (SZ) and autism spectrum disorder (ASD), are common, multi-factorial and multi-symptomatic disorders. Ample evidence implicates oxidative stress, deficient repair of oxidative DNA lesions and DNA damage in the development of these disorders. However, it remains unclear whether insufficient DNA repair and resulting DNA damage are causally connected to...
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