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Article

Prevalence of cancer susceptibility variants in patients with multiple Lynch syndrome related cancers.

Scientific reports - 20 Jul 2021

Choi Yoon Young, Shin Su-Jin, Lee Jae Eun, Madlensky Lisa, Lee Seung-Tae, Park Ji Soo, Jo Jeong-Hyeon, Kim Hyunki, Nachmanson Daniela, Xu Xiaojun, Noh Sung Hoon, Cheong Jae-Ho, Harismendy Olivier

Abstract excerpt

Along with early-onset cancers, multiple primary cancers (MPCs) are likely resulting from increased genetic susceptibility; however, the associated predisposition genes or prevalence of the pathogenic variants genes in MPC patients are often unknown. We screened 71 patients with MPC of the stomach, colorectal, and endometrium, sequencing 65 cancer predisposition genes. A subset of 19 patients with early-onset MPC...

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Identifiers

PMID: 34285288
DOI: 10.1038/s41598-021-94292-4
PMCID: PMC8292343

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