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Article

MicroRNA-363-3p promote the development of acute myeloid leukemia with RUNX1 mutation by targeting SPRYD4 and FNDC3B.

Medicine - 7 May 2021

Chen Yimin, Chen Shuyi, Lu Jielun, Yuan Danyun, He Lang, Qin Pengfei, Tan Huo, Xu Lihua

Abstract excerpt

BACKGROUND: Runt-related transcription factor 1 (RUNX1) is one of the most frequently mutated genes in most of hematological malignancies, especially in acute myeloid leukemia. In the present study, we aimed to identify the key genes and microRNAs based on acute myeloid leukemia with RUNX1 mutation. The newly finding targeted genes and microRNA associated with RUNX1 may benefit to the clinical treatment in acute...

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Source

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Identifiers

PMID: 33950983
DOI: 10.1097/MD.0000000000025807
PMCID: PMC8104143

Genes

RUNX1
FNDC3B
SPRYD4
APLNR
APP
C3AR1
CCR5
CXCL12
GNAI1
GNG11
HTR1F
P2RY14
PPBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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