[Clinical Characteristics of Acute Myeloid Leukemia Patients with RUNX1 Gene Mutation].

doi:10.19746/j.cnki.issn.1009-2137.2021.05.007

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Article

[Clinical Characteristics of Acute Myeloid Leukemia Patients with RUNX1 Gene Mutation].

Zhongguo shi yan xue ye xue za zhi - 1 Oct 2021

Ni Zeng-Feng, Ma Li-Jie, Shi Li-Li, Shen Pan-Li, Zhao Jian-Qiang

Abstract excerpt

OBJECTIVE: To investigate the incidence of Runt-related transcription factor 1 (RUNX1) gene and its associated gene mutations in patients with acute myeloid leukemia (AML), and analyze its clinical characteristics and prognosis. METHODS: The genomic DNA-PCR method was used to detect the exon of RUNX1 gene, and the gene mutations were analyzed by genetic sequencing. NPM1, DNMT3A, FLT3-ITD, IDH1/2, K/N-RAS, CEPBA,...

Topics

Core Binding Factor Alpha 2 Subunit
Humans
Karyotype
Leukemia, Myeloid, Acute
Leukocytes, Mononuclear
Mutation
Nucleophosmin

Source

Open in PubMed

Identifiers

PMID: 34627418
DOI: 10.19746/j.cnki.issn.1009-2137.2021.05.007

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