[RUNX1 gene mutations are associated with adverse prognosis of patients with acute myeloidleukemia].

doi:10.12122/j.issn.1673-4254.2020.11.10

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Article

[RUNX1 gene mutations are associated with adverse prognosis of patients with acute myeloidleukemia].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University - 30 Nov 2020

Yang Yanli, Li Tiantian, Geng Yinghua, Li Jun

Abstract excerpt

OBJECTIVE: To explore the rate and distribution of Runt- related transcription factor 1 (RUNX1) gene mutations in patients with acute myeloid leukemia (AML) and the correlation of these mutations with the clinical characteristics and survival outcomes of the patients. METHODS: The genomic DNA extracted from the bone marrow of 158 patients with newly diagnosed AML for PCR amplification of RUNX1 gene and sequence...

Topics

Core Binding Factor Alpha 2 Subunit
Humans
Leukemia, Myeloid, Acute
Mutation
Nucleophosmin
Prognosis
Remission Induction

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Identifiers

PMID: 33243739
DOI: 10.12122/j.issn.1673-4254.2020.11.10
PMCID: PMC7704376

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