Dysregulated innate immune signaling cooperates with RUNX1 mutations to transform an MDS-like disease to AML

Abstract excerpt

HSPCs, highlighting the necessity of TRAF6-dependent cell-intrinsic innate immune signaling in initiating and maintaining AML. These findings underscore the critical role of dysregulated cell-intrinsic innate immune signaling in driving preleukemic cells toward AML progression.

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