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Article

Association of Genetically Predicted Fibroblast Growth Factor-23 with Heart Failure

28 Jul 2022

Abstract excerpt

Background and objectives Elevated fibroblast growth factor-23 (FGF23) has been consistently associated with heart failure, particularly heart failure with preserved ejection fraction, among patients with CKD and in the general population. FGF23 may directly induce cardiac remodeling and heart failure. However, biases affecting observational studies impede robust causal inferences. Mendelian randomization...

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PMID: 35902130
DOI: 10.2215/cjn.00960122

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