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Histones and their practical application in bone tumors: Do I always need them?

Human pathology - 1 May 2024

Reith John D

Abstract excerpt

Historically, the diagnosis of giant cell-rich neoplasms arising in bone has been challenging owing to overlapping clinical and radiographic findings resulting in the difficult separation of several neoplasms, particularly when biopsy material is limited. However, with the discovery of the driver histone mutations in giant cell tumor of bone (GCTB) and chondroblastoma, as well as USP6 rearrangements in aneurysmal...

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PMID: 38307341
DOI: 10.1016/j.humpath.2024.01.010

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