Implementing accelerated dynamics to unravel the effects of high-fidelity Cas9 mutants on target DNA and guide RNA hybrid stability.

doi:10.1080/07391102.2022.2103032

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Article

Implementing accelerated dynamics to unravel the effects of high-fidelity Cas9 mutants on target DNA and guide RNA hybrid stability.

Journal of biomolecular structure & dynamics - 1 Jan 2000

Vora Dhvani Sandip, Jaiswal Atul Kumar, Sundar Durai

Abstract excerpt

The clustered regularly interspersed short palindromic repeats (CRISPR) and its associated nuclease (Cas9) offers a unique and easily reprogrammable system for editing eukaryotic genomes. Cas9 is guided to the target by an RNA strand, and precise edits are created by introducing double-stranded b...

Topics

CRISPR-Cas Systems
DNA
Mutation
Genome
RNA

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