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Article

RNA modification-related variants in genomic loci associated with body mass index.

Human genomics - 25 Jul 2022

Wu Jingyun, Wang Mimi, Han Limin, Zhang Huan, Lei Shufeng, Zhang Yonghong, Mo Xingbo

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWASs) have identified hundreds of loci for body mass index (BMI), but functional variants in these loci are less known. The purpose of this study was to identify RNA modification-related SNPs (RNAm-SNPs) for BMI in GWAS loci. BMI-associated RNAm-SNPs were identified in a GWAS of approximately 700,000 individuals. Gene expression and circulating protein levels affected...

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Body Mass Index
Genome-Wide Association Study
Genomics
Polymorphism, Single Nucleotide
RNA

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PMID: 35879730
DOI: 10.1186/s40246-022-00403-1
PMCID: PMC9316745

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