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Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity

27 Jul 2022

Abstract excerpt

Identifying genetic variants associated with lower waist-to-hip ratio can reveal new therapeutic targets for abdominal obesity. We use exome sequences from 362,679 individuals to identify genes associated with waist-to-hip ratio adjusted for BMI (WHRadjBMI), a surrogate for abdominal fat that is causally linked to type 2 diabetes and coronary heart disease. Predicted loss of function (pLOF) variants in INHBE...

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PMID: 35896531
DOI: 10.1038/s41467-022-31757-8

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