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Article

FLT3 functional low-frequency variant rs76428106-C is associated with susceptibility to systemic sclerosis.

Rheumatology (Oxford, England) - 6 Feb 2023

Martínez-López Javier, Kerick Martin, Ortiz-Fernández Lourdes, Acosta-Herrera Marialbert, Márquez Ana, Martín Javier

Abstract excerpt

OBJECTIVES: rs76428106-C, a low frequency polymorphism that affects the splicing of the FLT3 gene, has recently been associated with several seropositive autoimmune diseases. Here, we aimed to evaluate the potential implication of rs76428106-C in the susceptibility to systemic sclerosis (SSc). METHODS: We analysed a total of 26 598 European ancestry individuals, 9063 SSc and 17 535 healthy controls, to test the...

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Identifiers

PMID: 35876828
DOI: 10.1093/rheumatology/keac406
PMCID: PMC9910569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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