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Article

Usefulness of circulating tumor DNA from cerebrospinal fluid in recurrent high-grade glioma.

Revue neurologique - 1 Nov 2022

Fontanilles M, Deniel A, Marguet F, Beaussire L, Magne N, Derrey S, Blanchard F, Alexandru C, Coutant S, Laquerrière A, Clatot F, Di Fiore F, Sarafan-Vasseur N

Abstract excerpt

Molecular documentation at relapse of high-grade glioma is an urgent need for patient care. A prospective pilot study was conducted to assess the rate of mutation detection using targeted deep sequencing on circulating tumor DNA from cerebrospinal fluid (CSF) after chemo-radiotherapy based treatment. Fifteen patients were included: 13 patients with glioblastoma, 1 patient with gliosarcoma and 1 patient with...

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PMID: 35871016
DOI: 10.1016/j.neurol.2022.02.462

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