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Plasma ctDNA enables early detection of temozolomide resistance mutations in glioma

1 Jan 2024

Abstract excerpt

Background: Liquid biopsy based on circulating tumor DNA (ctDNA) is a novel tool in clinical oncology, however, its use has been limited in glioma to date, due to low levels of ctDNA. In this study, we aimed to demonstrate that sequencing techniques optimized for liquid biopsy in glioma patients can detect ctDNA in plasma with high sensitivity and with potential clinical utility. Methods: We investigated 10...

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PMID: 38596716
DOI: 10.1093/noajnl/vdae041

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