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Phenotypic and Functional Alterations of Dendritic Cells Induced by Human Herpesvirus 6 Infection

18 Sept 2002

Abstract excerpt

Human herpesvirus 6 (HHV-6) has a tropism for T lymphocytes and monocytes/macrophages, suggesting that HHV-6 infection affects the immunosurveillance system. In the present study, we investigated the HHV-6-induced phenotypic and functional alterations of dendritic cells (DCs), which are professional antigen-presenting cells. HHV-6 infection of monocyte-derived immature DCs appeared to induce the up-regulation of...

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PMID: 12239310
DOI: 10.1128/jvi.76.20.10338-10345.2002

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