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Article

Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells.

Proceedings of the National Academy of Sciences of the United States of America - 14 Nov 2006

Sato Ayuko, Linehan Melissa M, Iwasaki Akiko

Abstract excerpt

Dendritic cells (DCs) express multiple Toll-like receptors (TLR) in distinct cellular locations. Herpes simplex viruses (HSV) have been reported to engage both the surface TLR2 and intracellular TLR9 in conventional DCs. However, the contributions of these TLRs in recognition of HSV and the induction of proinflammatory cytokines in DCs remain unclear. Here, we demonstrate that a rare population of HSV, both in...

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Identifiers

PMID: 17085599
DOI: 10.1073/pnas.0605102103
PMCID: PMC1859932

Genes

TLR2
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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