Genomic Analysis of Circulating Tumor DNA in 3,334 Patients with Advanced Prostate Cancer Identifies Targetable BRCA Alterations and AR Resistance Mechanisms.

doi:10.1158/1078-0432.CCR-20-4805

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Article

Genomic Analysis of Circulating Tumor DNA in 3,334 Patients with Advanced Prostate Cancer Identifies Targetable BRCA Alterations and AR Resistance Mechanisms.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2021

Tukachinsky Hanna, Madison Russell W, Chung Jon H, Gjoerup Ole V, Severson Eric A, Dennis Lucas, Fendler Bernard J, Morley Samantha, Zhong Lei, Graf Ryon P, Ross Jeffrey S, Alexander Brian M, Abida Wassim, Chowdhury Simon, Ryan Charles J, Fizazi Karim, Golsorkhi Tony, Watkins Simon P, Simmons Andrew, Loehr Andrea, Venstrom Jeffrey M, Oxnard Geoffrey R

Abstract excerpt

PURPOSE: Comprehensive genomic profiling (CGP) is of increasing value for patients with metastatic castration-resistant prostate cancer (mCRPC). mCRPC tends to metastasize to bone, making tissue biopsies challenging to obtain. We hypothesized CGP of cell-free circulating tumor DNA (ctDNA) could offer a minimally invasive alternative to detect targetable genomic alterations (GA) that inform clinical care....

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PMID: 33558422
DOI: 10.1158/1078-0432.CCR-20-4805
PMCID: PMC9295199

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