Article
Mutation spectrum and prevalence of BRCA1 and BRCA2 genes in patients with familial and early-onset breast/ovarian cancer from Tunisia.
Clinical genetics - 1 Feb 2015
Riahi A, Kharrat M, Ghourabi M E, Khomsi F, Gamoudi A, Lariani I, May A E, Rahal K, Chaabouni-Bouhamed H
Abstract excerpt
The contribution of BRCA1/BRCA2 mutations to hereditary breast cancer in the Tunisian population has not been accurately estimated. The purpose of our study was to estimate the incidence and spectrum of pathogenic mutations in BRCA1/2 genes in early onset and familial breast/ovarian cancer among Tunisian women. To identify predictive factors for BRCA1/2 mutations, we screened the entire coding sequences and...
Topics
- Adult
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Female
- Humans
- Mutation
- Ovarian Neoplasms
- Tunisia