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Article

UVB-Induced Skin Autoinflammation Due to Nlrp1b Mutation and Its Inhibition by Anti-IL-1β Antibody.

Frontiers in immunology - 1 Jan 2022

Murase Yuya, Takeichi Takuya, Koseki Jun, Miyasaka Yuki, Muro Yoshinao, Ohno Tamio, Shimamura Teppei, Akiyama Masashi

Abstract excerpt

NLRP1 (NACHT and leucine-rich repeat-containing protein family, pyrin domain-containing protein 1) is an innate immune sensor that is involved in the formation of inflammasome complexes. NLRP1 hyperactivity has been reported to cause inherited autoinflammatory diseases including familial keratosis lichenoides chronica and NLRP1-associated autoinflammation with arthritis and dyskeratosis. We generated Nlrp1b (the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35784371
DOI: 10.3389/fimmu.2022.876390
PMCID: PMC9248282

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