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Article

Ribotoxic stress through p38 mitogen-activated protein kinase activates in vitro the human pyrin inflammasome.

The Journal of biological chemistry - 19 Apr 2013

Yu Je-Wook, Farias Andrew, Hwang Inhwa, Fernandes-Alnemri Teresa, Alnemri Emad S

Abstract excerpt

Human pyrin with gain-of-function mutations in its B30.2/SPRY domain causes the autoinflammatory disease familial Mediterranean fever by assembling an ASC-dependent inflammasome that activates caspase-1. Wild-type human pyrin can also form an inflammasome complex with ASC after engagement by autoinflammatory PSTPIP1 mutants. How the pyrin inflammasome is activated in the absence of disease-associated mutations is...

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Source

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Identifiers

PMID: 23479736
DOI: 10.1074/jbc.M112.448795
PMCID: PMC3630843

Genes

PSTPIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Ribotoxic stress through p38 mitogen-activated protein kinase activates in vitro the human pyrin inflammasome.PMID 23479736Read ↗

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