Article
Clinical significance of FLT3-ITD/CEBPA mutations and minimal residual disease in cytogenetically normal acute myeloid leukemia after hematopoietic stem cell transplantation.
Journal of cancer research and clinical oncology - 1 Sept 2021
Wang Hong, Li Xue-Qian, Chu Tian-Tian, Han Shi-Yu, Qi Jia-Qian, Tang Ya-Qiong, Qiu Hui-Ying, Fu Cheng-Cheng, Tang Xiao-Wen, Ruan Chang-Geng, Wu De-Pei, Han Yue
Abstract excerpt
PURPOSE: Genetic changes have prognostic significance in cytogenetically normal acute myeloid leukemia (CN-AML). We set out to evaluate the prognostic of 6 gene mutations in CN-AML. METHODS: We performed a mutational analysis and evaluated prognostic findings of six genes (NPM1, CEBPA, DNMT3A, FLT3-ITD, FLT3-TKD, and C-KIT) in 428 CN-AML patients at our center over 10 years. RESULTS: A total of 282 patients...
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