Cytogenetic risk classification maintains its prognostic significance in transplanted FLT3-ITD mutated acute myeloid leukemia patients: On behalf of the acute leukemia working party/European society of blood and marrow transplantation.

doi:10.1002/ajh.26442

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Cytogenetic risk classification maintains its prognostic significance in transplanted FLT3-ITD mutated acute myeloid leukemia patients: On behalf of the acute leukemia working party/European society of blood and marrow transplantation.

American journal of hematology - 1 Mar 2022

Nagler Arnon, Labopin Myriam, Craddock Charles, Socié Gerard, Yakoub-Agha Ibrahim, Gedde-Dahl Tobias, Niittyvuopio Riitta, Byrne Jennifer Louise, Cornelissen Jan J, Labussière-Wallet Hélène, Arcese William, Milpied Noel, Esteve Jordi, Canaani Jonathan, Mohty Mohamad

Abstract excerpt

FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutational status is a pivotal prognosticator in acute myeloid leukemia (AML) patients and significantly increases the risk of disease relapse. However, it remains unclear whether in FLT3-ITD patients referred for allogeneic stem cell transplantation (allo-SCT), baseline cytogenetics significantly impacts clinical outcome. Using the European...

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PMID: 34978724
DOI: 10.1002/ajh.26442

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