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Article

Phagocytosis converts infiltrated monocytes to microglia-like phenotype in experimental brain ischemia.

Journal of neuroinflammation - 18 Jul 2022

Ju Hyunwoo, Park Keun Woo, Kim Il-Doo, Cave John W, Cho Sunghee

Abstract excerpt

BACKGROUND: Monocyte-derived macrophages (MDMs) and microglia elicit neural inflammation and clear debris for subsequent tissue repair and remodeling. The role of infiltrating MDMs in the injured brain, however, has been controversial due to overlapping antigen expression with microglia. In this study, we define the origin and function of MDMs in cerebral ischemia. METHODS: Using adoptive transfer of GFP+...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35850727
DOI: 10.1186/s12974-022-02552-5
PMCID: PMC9295522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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