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Research progress on the mechanisms of CSF3R mutations in leukemogenesis and treatment strategies

14 Aug 2025

Abstract excerpt

Leukemia is a malignant clonal disease originating from hematopoietic stem cells. Its pathogenesis is associated with multiple factors, including biological, physical, chemical, genetic, and other hematological diseases. Previous studies have shown that a high mutation rate (>80%) of colony-stimulating factor receptor 3 (CSF3R) is observed in chronic neutrophilic leukemia (CNL) patients, and these mutations...

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PMID: 40813694
DOI: 10.1186/s12935-025-03941-5

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