Th17/Treg dysregulation in allergic asthmatic children is associated with elevated notch expression

Abstract excerpt

BACKGROUND: Notch signaling pathway is critically involved in the differentiation of T helper (Th) cells, key players in the pathogenesis of allergic diseases. OBJECTIVE: The study is to explore whether Th17/Treg dysregulation in children with allergic asthma (AA) is associated with alteration of Notch expression. METHODS: Thirty-five patients with AA and thirty-five healthy control children were selected. Flow...

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