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Transcriptomic Exploration Combined With Experimental Validation: Uncovering The Potential Value Of Ammonia Death-Related Biomarkers In Hepatic Ischemia-Reperfusion Injury

2025-07-29

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Hepatic ischemia-reperfusion injury (HIRI) is considered the primary cause of postoperative liver dysfunction and failure. Ammonia-induced cell death, characterized by lysosomal and mitochondrial damage due to ammonia accumulation, may be involved in the pathogenesis of HIRI. <bold>Methods</bold> The GSE151648 and GSE12720 datasets were obtained from the Gen...

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Literature Corpus work
02b691c0-e5c9-5cab-9756-8f96bef52473
DOI
10.21203/rs.3.rs-7000864/v1
Open publication

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