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Single-Cell Transcriptomic Analysis of Livers During NLRP3 Inflammasome Activation Reveals a Novel Immune Niche

2021-03-31

Abstract excerpt

The NOD-like receptor protein 3 (NLRP3) inflammasome is a central contributor to human acute and chronic liver disease, yet the molecular and cellular mechanisms by which its activation precipitates injury remain incompletely understood. Here, we present single cell transcriptomic profiling of livers from a global transgenic Tamoxifen-inducible constitutively-activated Nlrp3 A350V mutant mouse, and we investigate...

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Literature Corpus work
183e29f7-a58a-565f-bb57-9f7227174d96
DOI
10.1101/2021.03.31.437725
Open publication

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Single-Cell Transcriptomic Analysis of Livers During NLRP3 Inflammasome Activation Reveals a Novel Immune NicheDOI 10.1101/2021.03.31.437725
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