Article
Tacrolimus CYP3A Single-Nucleotide Polymorphisms and Preformed T- and B-Cell Alloimmune Memory Improve Current Pretransplant Rejection-Risk Stratification in Kidney Transplantation.
Frontiers in immunology - 1 Jan 2022
Crespo Elena, Vidal-Alabró Anna, Jouve Thomas, Fontova Pere, Stein Maik, Mocka Sonila, Meneghini Maria, Sefrin Anett, Hruba Petra, Gomà Montserrat, Torija Alba, Donadeu Laura, Favà Alex, Cruzado Josep M, Melilli Edoardo, Moreso Francesc, Viklicky Ondrej, Bemelman Frederike, Reinke Petra, Grinyó Josep, Lloberas Nuria, Bestard Oriol
Abstract excerpt
Achieving fast immunosuppression blood exposure after kidney transplantation is key to abrogating both preformed and de novo anti-donor humoral and cellular alloresponses. However, while tacrolimus (TAC) is the cornerstone immunosuppressant inhibiting adaptive alloimmunity, its blood exposure is directly impacted by different single-nucleotide polymorphisms (SNPs) in CYP3A TAC-metabolizing enzymes. Here, we...
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