Article
Development of De Novo Donor-specific HLA Antibodies and AMR in Renal Transplant Patients Depends on CYP3A5 Genotype.
Transplantation - 1 May 2022
Friebus-Kardash Justa, Nela Ejona, Möhlendick Birte, Kribben Andreas, Siffert Winfried, Heinemann Falko Markus, Eisenberger Ute
Abstract excerpt
BACKGROUND: The single-nucleotide polymorphism CYP3A5 rs776746 is related to a reduction in the metabolizing activity of the CYP3A5 enzyme. People carrying at least one copy of the wild-type allele, defined as CYP3A5 expressers, exhibit higher clearance and lower trough concentrations of tacrolimus than homozygous nonexpressers, and this difference may affect alloimmunization and allograft function. METHODS: We...
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