Article
Genomic profiling of Richter's syndrome: recurrent lesions and differences with de novo diffuse large B-cell lymphomas.
Hematological oncology - 1 Jun 2010
Scandurra Marta, Rossi Davide, Deambrogi Clara, Rancoita Paola M V, Chigrinova Ekaterina, Mian Michael, Cerri Michaela, Rasi Silvia, Sozzi Elisa, Forconi Francesco, Ponzoni Maurilio, Moreno Santiago M, Piris Miguel A, Inghirami Giorgio, Zucca Emanuele, Gattei Valter, Rinaldi Andrea, Kwee Ivo, Gaidano Gianluca, Bertoni Francesco
Abstract excerpt
Richter's syndrome (RS) represents the transformation of chronic lymphocytic leukaemia (CLL) to aggressive lymphoma and is mostly represented by diffuse large B-cell lymphoma (DLBCL), with a post-germinal centre (GC) phenotype, clonally related to the pre-existing CLL. RS has a very poor prognosis and its pathogenetic mechanisms are poorly understood. In order to gain additional hints in RS pathogenesis, we...
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