Article
The MitoAging Project: Single nucleotide polymorphisms (SNPs) in mitochondrial genes and their association to longevity.
Mitochondrion - 1 Sept 2022
Castañeda Verónica, Haro-Vinueza Alissen, Salinas Ivonne, Caicedo Andrés, Méndez Miguel Ángel
Abstract excerpt
Mitochondrial dysfunction is a major hallmark of aging. Mitochondrial DNA (mtDNA) mutations (inherited or acquired) may cause a malfunction of the respiratory chain (RC), and thus negatively affect cell metabolism and function. In contrast, certain mtDNA single nucleotide polymorphisms (SNPs) may be beneficial to mitochondrial electron transport chain function and the extension of cellular health as well as...
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