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Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis.

Mechanisms of ageing and development - 31 Jul 2000

Tanaka M, Gong J, Zhang J, Yamada Y, Borgeld H J, Yagi K

Abstract excerpt

Mitochondria are not only the major site of ATP production in cells but also an important source of reactive oxygen species (ROS) under certain pathological conditions. Because mitochondrial DNA (mtDNA) in the mitochondrial matrix is exposed to ROS that leak from the respiratory chain, this extranuclear genome is prone to mutations. Therefore, the mitochondrial genome is a rich source of single nucleotide...

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Identifiers

PMID: 10996007
DOI: 10.1016/s0047-6374(00)00149-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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