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Posterior cingulate cortex reveals an expression profile of resilience in cognitively intact elders

21 Jun 2022

Abstract excerpt

The posterior cingulate cortex, a key hub of the default mode network, underlies autobiographical memory retrieval and displays hypometabolic changes early in Alzheimer disease. To obtain an unbiased understanding of the molecular pathobiology of the aged posterior cingulate cortex, we performed RNA sequencing (RNA-seq) on tissue obtained from 26 participants of the Rush Religious Orders Study (11 males/15...

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PMID: 35813880
DOI: 10.1093/braincomms/fcac162

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