Article
Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders.
Pharmacogenetics and genomics - 1 Oct 2009
Hammer Christian, Kapeller Johannes, Endele Max, Fischer Christine, Hebebrand Johannes, Hinney Anke, Friedel Susann, Gratacòs Mònica, Estivill Xavier, Fichter Manfred, Fernández-Aranda Fernando, Ehrlich Stefan, Rappold Gudrun, Niesler Beate
Abstract excerpt
OBJECTIVE: As a key player in modulating both human physiological and behavioural functions including anxiety, perception and in particular appetite, serotonin (5-hydroxytryptamine, 5-HT) is likely to be involved in the aetiology of eating disorders. Studies showing serotonin receptor type 3 (5-HT3) receptors to mediate food intake depression (anorexic response) have triggered our interest in investigating the...
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