Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rare Variants of the Serotonin Transporter Are Associated With Psychiatric Comorbidity in Irritable Bowel Syndrome.

Biological research for nursing - 1 Jul 2016

Kohen Ruth, Tracy Julia H, Haugen Eric, Cain Kevin C, Jarrett Monica E, Heitkemper Margaret M

Abstract excerpt

Alterations in serotonin signaling are suspected in the pathophysiology of irritable bowel syndrome (IBS). By modulating the extracellular reuptake of serotonin, the serotonin transporter (SERT) acts as a key regulator of the bioavailability of serotonin. This study is the first to investigate the impact of rare SERT variants (i.e., those with a minor allele frequency of < 1%) on the risk for IBS,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to Comorbidity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genetic Variation

Share to Irritable Bowel Syndrome

Share to Mental Disorders

Share to Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26912503
DOI: 10.1177/1099800416633296
PMCID: PMC5942482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rare Variants of the Serotonin Transporter Are Associated With Psychiatric Comorbidity in Irritable Bowel Syndrome.PMID 26912503Read ↗

Serotonin transporter: gene, genetic disorders, and pharmacogenetics.Semantic proximity Read ↗

Relationship of SERT polymorphisms to depressive and anxiety symptoms in irritable bowel syndrome.Semantic proximity Read ↗

Serotonin transporter gene polymorphisms in Southwestern Iranian patients with irritable bowel syndrome.Semantic proximity Read ↗

The serotonin transporter polymorphism rs25531 is associated with irritable bowel syndrome.Semantic proximity Read ↗

The genetics of the serotonin transporter and irritable bowel syndromeSemantic proximity Read ↗

Genetic epidemiology of irritable bowel syndrome.Semantic proximity Read ↗

Serotonin Transporter Gene Polymorphism in Irritable Bowel SyndromeSemantic proximity Read ↗

The serotonin transporter gene polymorphism (5-HTTLPR) and irritable bowel syndrome: a meta-analysis of 25 studies.Semantic proximity Read ↗

Serotonin transporter gene polymorphism and irritable bowel syndrome.Semantic proximity Read ↗

Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndromeSemantic proximity Read ↗

Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study.Semantic proximity Read ↗

Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.