Epithelial Cell Transforming Sequence 2 in Human Oral Cancer

doi:10.1371/journal.pone.0014082

Article

Epithelial Cell Transforming Sequence 2 in Human Oral Cancer

29 Nov 2010

Abstract excerpt

BACKGROUND: Epithelial cell transforming sequence 2 (ECT2) is a guanine nucleotide exchange factor for Rho family GTPase, which has been implicated in the malignant phenotype of human cancers. Little is known about the effect of a high level of ECT2 in regulating oral cancer cell behavior. In this study, we investigated the involvement of ECT2 in oral squamous cell carcinoma (OSCC). METHODOLOGY/PRINCIPAL...

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