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Article

A carcinogenic trigger to study the function of tumor suppressor genes in Schmidtea mediterranea.

Disease models & mechanisms - 16 Aug 2018

Van Roten Andromeda, Barakat Amal Zohir Abo-Zeid, Wouters Annelies, Tran Thao Anh, Mouton Stijn, Noben Jean-Paul, Gentile Luca, Smeets Karen

Abstract excerpt

Planarians have been long known for their regenerative ability, which hinges on pluripotency. Recently, however, the planarian model has been successfully established for routine toxicological screens aimed to assess overproliferation, mutagenicity and tumorigenesis. In this study, we focused on planarian tumor suppressor genes (TSGs) and their role during chemically induced carcinogenic stress in Schmidtea...

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Source

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Identifiers

PMID: 29967069
DOI: 10.1242/dmm.032573
PMCID: PMC6176991

Genes

GLIPR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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