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Article

Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation.

Nature cell biology - 1 Apr 2007

Gareus Ralph, Huth Marion, Breiden Bernadette, Nenci Arianna, Rösch Nora, Haase Ingo, Bloch Wilhelm, Sandhoff Konrad, Pasparakis Manolis

Abstract excerpt

The kinase IKK1 (also known as IKKalpha) was previously reported to regulate epidermal development and skeletal morphogenesis by acting in keratinocytes to induce their differentiation in an NF-kappaB independent manner. Here, we show that mice with epidermal keratinocyte-specific IKK1 ablation (hereafter referred to as IKK1(EKO)) develop a normally differentiated stratified epidermis, demonstrating that the...

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Identifiers

PMID: 17351639
DOI: 10.1038/ncb1560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation.PMID 17351639Read ↗

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