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Single-cell analysis of 2,3,7,8-tetrachlorodibenzo- <i>p</i> -dioxin (TCDD)-treated murine skin demonstrates that sebaceous gland differentiation precedes <i>Ahr</i> -dependent seboatrophy with elevated expression of infundibular <i>Blimp1</i>

2026-07-23

Abstract excerpt

In humans, 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) induces chloracne, a skin condition that presents with acanthosis, hyperkeratosis, comedones, and sebaceous gland (SG) atrophy (seboatrophy). Although chloracne-like phenotypes have been reported in TCDD-treated mice, the underlying mechanisms remain poorly understood. Previous studies showed that TCDD-induced CYP1A1 protein is expressed in LRIG1+ progenitor...

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Literature Corpus work
53e3364e-eec1-5c83-9c38-ae4200051b19
DOI
10.64898/2026.07.22.740060
Open publication

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Single-cell analysis of 2,3,7,8-tetrachlorodibenzo- <i>p</i> -dioxin (TCDD)-treated murine skin demonstrates that sebaceous gland differentiation precedes <i>Ahr</i> -dependent seboatrophy with elevated expression of infundibular <i>Blimp1</i>DOI 10.64898/2026.07.22.740060
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