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Article

Molecular dissection of a hyper-aggressive CBFB-MYH11/FLT3-ITD-positive acute myeloid leukemia.

Journal of translational medicine - 6 Jul 2022

Lo Iudice Gabriele, De Bellis Eleonora, Savi Arianna, Guarnera Luca, Massacci Alice, De Nicola Francesca, Goeman Frauke, Ottone Tiziana, Divona Mariadomenica, Pallocca Matteo, Fanciulli Maurizio, Voso Maria Teresa, Ciliberto Gennaro

Abstract excerpt

Acute Myeloid Leukaemia (AML) is a haematological malignancy showing a hypervariable landscape of clinical outcomes and phenotypic differences, explainable by heterogeneity at the cellular and molecular level. Among the most common genomic alterations, CBFB-MYH11 rearrangement and FLT3-ITD gene mutations, have opposite clinical significance and are unfrequently associated. We present here a Molecular Case Report...

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Identifiers

PMID: 35794567
DOI: 10.1186/s12967-022-03486-5
PMCID: PMC9258203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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