Article
PCR-Fluo-ASXL1-FA: A fast, sensitive and inexpensive complementary method to detect ASXL1 mutations in haematological malignancies.
International journal of laboratory hematology - 1 Oct 2022
Friedrich Chloé, Zalmaï Loria, Gay Juliette, Coude Marie Magdeleine, Bravetti Clotilde, Vazquez Romain, Temple Marie, Duroyon Eugénie, Darnige Luc, Decroocq Justine, Alary Anne Sophie, Kosmider Olivier
Abstract excerpt
INTRODUCTION: The additional sex combs like 1 (ASXL1) gene is frequently mutated in a number of haematological neoplasms. The c.1934dupG, known to be the most common alteration in ASXL1, is associated with poor clinical outcome. A systematic determination of ASXL1 mutational status in myeloid malignancies is therefore necessary for prognostic stratification. METHODS: Because direct sequencing is not sensitive and...
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