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Article

Highly variable mutational profile of ASXL1 in myelofibrosis.

European journal of haematology - 1 Oct 2016

Sorigué Marc, Ribera Josep-Maria, García Olga, Cabezón Marta, Vélez Patricia, Marcé Silvia, Xicoy Blanca, Fernández Cristalina, Buch Joan, Cortes Montserrat, Plensa Esther, Gallardo David, Boqué Concepción, Feliu Evarist, Zamora Lurdes

Abstract excerpt

OBJECTIVE: Somatic mutations in ASXL1 seem to have a negative prognostic impact in patients with several myeloid neoplasms, including myelofibrosis (MF). The aim of this work was to determine the prevalence and profile of ASXL1 mutations in MF. METHODS: We analyzed mutations in ASXL1 in 70 consecutive MF patients from 8 Spanish hospitals by means of Sanger sequencing, as well as JAK2, CALR, and MPL mutations....

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Source

Identifiers

PMID: 26714837
DOI: 10.1111/ejh.12731

Genes

ASXL1
CALR
JAK2
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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